A new study reveals how lactic acid released by bacteria in wounds dampens the immune response, hindering healing and promoting chronic infections. Research indicates this acidity suppresses immune cell activation and creates an environment where other bacteria can thrive. The study used mouse wound models to show how bacteria that are unable to produce lactic acid were cleared much faster.
The mouse wound infection model demonstrated that wounds infected with E. faecalis had dampened immunity, allowing the bacteria to persist and even enabling co-infecting bacteria like E. coli to thrive. — SMART AMR
When infected wounds – often arising from surgery, diabetes or everyday injuries – fail to heal, they can become chronic infections that linger for weeks and become difficult to treat. This places a heavy burden on patients and healthcare systems, with the risk of serious complications such as amputations.
A new study has now uncovered a key mechanism that explains why these infections are so difficult to treat and why they frequently become more complex over time. Led by researchers from the Singapore‑MIT Alliance for Research and Technology’s Antimicrobial Resistance interdisciplinary research group, the multinational team discovered how a common bacterium found in wounds,, releases large amounts of lactic acid during infection, acidifying the surrounding tissue environment.
This acidity suppresses the activation of macrophages – immune cells that normally help to clear infections – and interferes with several important internal processes that help the cell recognise and respond to infection. As a result, the mechanisms that cells rely on to send out “danger” signals are suppressed, effectively “switching off” the body’s line of defence.to persist far longer than it should and creates a weakened environment where other bacteria, such as
This results in persistent, polymicrobial wound infections, such as diabetic foot ulcers and post‑surgical complications, where multiple bacterial species make treatment more challenging., the researchers showed through mouse wound models that strains ofunable to produce lactic acid were cleared much faster, with the wounds showing stronger immune activity.
Wound Infections Lactic Acid Immune Response Bacteria Chronic Infections
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