Insulin-blocking protein may be the secret to queen ants’ long lives

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Insulin-blocking protein may be the secret to queen ants’ long lives
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Indian jumping ant queens live nine times longer than worker females in the same colony, which may be due to insulin-blocking proteins they produce once they begin reproduction

ant dies naturally, a handful of previously infertile female worker ants vie for her position. As these “pseudoqueens” start producing eggs, their lifespan increases from months to years.

Desplan and his colleagues plucked queen ants from their colonies to create pseudoqueens, which then churned out significantly more insulin than the female worker ants in the colony.ants have two insulin signalling pathways: one that drives egg production, called MAPK, and one that plays a role in ageing, called AKT.

This work “pushes well beyond what we knew before about the biochemistry of insulin signalling in ants”, saysat Harvard University, who wasn’t involved in the research. Chandra says he would still like to see if blocking the AKT pathway extends the lives of worker ants but acknowledges such a study would take years because of the species’ lifespan. “Without doing that, it’s very hard to know whether this actually matters for lifespan,” he says.

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