For patients with high-risk non–muscle-invasive bladdercancer, the gold-standard systemic therapy for preventing disease recurrence and progression following transurethral resection is bacillus Calmette-Guérin. OncTwitter
senior author Vignesh T. Packiam, MD, said that he is confident about the benefits of sequential gemcitabine-docetaxel in patients with high-risk NMIBC.
The team looked at data on 174 patients with high-risk treatment naive NMIBC who received BCG and 138 who received gemcitabine-docetaxel from January 2011 through December 2021.All patients underwent complete transurethral resection of bladder tumors, followed by either sequential intravesical gemcitabine 1 g and docetaxel 37.5 mg, or 1 vial of BCG.
In multivariable regression analyses controlling for age, sex, treatment year, and presence or absence of carcinoma in situ, the chemotherapy combination was associated with both better high-grade RFS and overall RFS than BCG.
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