Findings offer insight into biological mechanisms, pointing to possible treatments. An NIH study on twelve Long COVID patients found differences in immune cell profiles and autonomic dysfunction, contributing to the understanding of the condition and potentially leading to better diagnoses and ne
A study at the National Institutes of Health involving twelve people with persistent neurological symptoms after SARS-CoV-2 infection found differences in immune cell profiles and autonomic dysfunction. Long COVID symptoms include fatigue, “brain fog,” and sleep disturbances, which can last for months.
The results showed that people with Long COVID had lower levels of CD4+ and CD8+ T cells—immune cells involved in coordinating the immune system’s response to viruses—compared to healthy controls. Researchers also found increases in the numbers of B cells and other types of immune cells, suggesting that immune dysregulation may play a role in mediating Long COVID.
Taken together, the findings add to growing evidence that widespread immunological and autonomic nervous system changes may contribute to Long COVID. The results may help researchers better characterize the condition and explore possible therapeutic strategies, such as immunotherapy.
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