🔬 Unlocking the mysteries of long COVID: A renowned researcher highlights critical elements crucial for the success of upcoming clinical trials exploring this condition.
Endpoints should be high-impact and aim for large improvements that have clinical significance over small improvements that do not have clinical significance. natural killer cell functioning, cerebral blood flow, T-cell functioning, levels of reactivated herpesviruses, blood lactate levels, and microclots, as testing becomes available.
Mental health outcomes shouldn't be primary endpoints, except where a trial is targeting a specific mental health condition because of COVID . If mental health conditions are tracked secondarily, it's vital not to use questionnaires that include physical symptoms like fatigue, difficulty concentrating, difficulty sleeping, or palpitations, as these artificially increase
and anxiety scores in chronically ill respondents. Tools that include physical symptoms can be replaced with scales like the PHQ-2, GAD-7, HADS, or PROMIS-29 subscales.without corresponding improvement in the ME/CFS subtype, caution should be taken when using cytokines as endpoints.A proportion of people with long COVID will recover in the early months after infection.
But where resources are abundant, it is ideal for trials to additionally look at whether the treatments can help patients in the early months recover and prevent progression to the later stage.immune change in the first few yearsBecause of this and the possibility that other markers follow the same pattern, disease duration should be a core feature of all analyses and trial designs.
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