Science, Space and Technology News 2023
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“This research, done in tiny nematode worms, has immense implications for human dietary choices and the propensity to overeat certain foods,” said Buck professor Pankaj Kapahi, PhD, the senior author of the study. “Processed modern diets enriched with AGEs are tempting to eat but we know very little about their long-term consequences on our health.
To uncover the biochemical signaling pathway responsible for overeating in normal healthy worms, the researchers purified some well-studied AGEs and found two of them that increased eating. They further explored one of the compounds to find out the signaling mechanism. They showed that a particular mutation increased food intake, mediated by a particular AGE . Further analysis revealed a tyramine-dependent pathway was responsible.
“Understanding this signaling pathway may help us to understand overeating due to modern AGEs-rich diets,” said Kapahi.
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