A single cell holds 2-3 meters of DNA, necessitating a compact storage method. This is achieved through chromatin, a complex formed by DNA coiled around proteins called histones. In three-dimensional space, chromatin is intricately folded into a multi-layered organization consisting of loops, domain
Chromosomes in cells with whole genome doubling. Credit: Elisa Oricchio/Giovanni Ciriello , necessitating a compact storage method. This is achieved through chromatin, a complex formed by DNA coiled around proteins called histones. In three-dimensional space, chromatin is intricately folded into a multi-layered organization consisting of loops, domains, and compartments, ultimately forming chromosomes.
The researchers looked at cells that lack the tumor suppressor gene p53, making them prone to WGD. They found that WGD leads to a reduction in the segregation of chromatin’s structural elements, such as loops, domains, and compartments, upending its careful organization in the cell. The researchers also found that the effects of WGD on chromatin organization are largely independent of chromosomal alterations, meaning that loss of chromatin segregation and chromosomal instability are complementary mechanisms that work together to promote cancer development.
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