Neuronal Molecule Makes Prostate Cancer More Aggressive Researchers discover a potential therapeutic avenue against an aggressive form of prostate cancer. Prostate cancer is the second most common cancer and the second leading cause of cancer death among American men. Now, researchers have disc
Prostate cancer is the second most common cancer and cause of cancer-related death among American men. Researchers have identified crucial molecular factors that contribute to the development of an extremely aggressive form known as neuroendocrine prostate cancer, which currently lacks effective treatments. This discovery opens up new possibilities for developing therapeutics to combat this aggressive form of the disease.
Adenocarcinoma prostate cancers can progress into neuroendocrine prostate cancer. Until now, how this transition occurs has been a mystery. The finding “was a big discovery,” Dr. Languino says, who is also a researcher with the Sidney Kimmel Cancer Center – Jefferson Health. That’s because NgR2 is a protein found in nerve cells, where it contributes to neuronal functions. It has never before been studied in cancer, of any kind.
When Dr. Languino and her team lowered the amount of NgR2 in neuroendocrine prostate cancer cells, neuroendocrine markers also decreased. The results suggest that NgR2 plays a role in the development of neuroendocrine prostate cancer. Lowering the amount of NgR2 also reduced the ability of cancer cells to grow and move, indicating that NgR2 may have a hand in cancer spreading to other parts of the body, in a process known as metastasis. Metastases are often what make cancers fatal.
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