May 20 (Reuters) - Bristol Myers Squibb said on Wednesday it is partnering with Anthropic to make its Claude AI model available to over 30,000 employees in an effort to accelerate the discovery, development and delivery of new medicines.
Although statins can save lives, some patients refuse them because of their significant side effects. — TNS More than 92 million American adults take a statin drug to manage high blood cholesterol, but one in 10 of those prescribed statins suffer muscle pain and fatigue side effects strong enough to make them quit.
“I’ve had patients who’ve been prescribed statins, and they refused to take them because of the side effects,” study lead author and Columbia University cardiologist Prof Dr Andrew Marks told SciTechDaily.com. “It’s the most common reason patients quit statins, and it’s a very real problem that needs a solution.
” Along with colleagues at the University of Rochester, Prof Marks’ paper described how statins cause muscle tissue to leak calcium by interfering with a protein inside cells that stores the element crucial to muscle function. Disrupting that protein causes calcium to leak into the cell continuously, potentially damaging muscle tissue.of Clinical InvestigationToo much cholesterol circulating in the blood can clog arteries and increase the risk of stroke or heart attack.
Statins help by blocking a liver enzyme needed to produce cholesterol, lowering low-density or “bad” cholesterol in the blood. Low-dose statins, combined with blood pressure medication, could help people with moderate risks avoid serious complications like heart attacks or strokes, according to the American Heart Association. The new findings offer two potential solutions to the aches and pains of statin side effects.
The other is to add another drug, already under testing in mice, to help stabilise the calcium channel in these proteins. – By Karl Hille/The Baltimore Sun/Tribune News Service
Statins Drugs Cholesterol Pain
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