Genetics, smoking and mediations can all influence how our bodies react to caffeinated beverages
I have never felt the effects of caffeine. I can drink coffee at 10 o’clock at night and promptly fall asleep. Following the suggestion of a caffeine researcher, I once spent a month drinking nothing but decaf, then switched back to a month of fully caffeinated beverages. Again, nothing.
It turns out, the coffee experience is not the same for everyone. How we respond to coffee, whether we like the taste and even how it influences our risk for heart attack or hypertension are all largely determined by our genes.And it’s one gene in particular — CYP1A2 — that appears to strongly influence our body’s sensitivity to caffeine.
But the speed of your caffeine metabolism isn’t the only factor influencing how you feel when you drink coffee or caffeinated beverages.Caffeine works by binding to adenosine receptors in the brain ,The number of these receptors in your brain is determined by both genetics and how much caffeine you routinely consume. For example, if you consistently drink a lot of coffee, and those channels are consistently blocked, the body compensates by creating more adenosine receptors.
“If you have genetic variants that allow you to metabolize caffeine more quickly, you're more likely to consume more caffeine and possibly just tolerate a higher level,” says Marilyn Cornelis, an associate professor of preventive medicine at Northwestern University’s Feinberg School of Medicine., she found that individuals with genetic variants associated with high caffeine sensitivity were less likely to enjoy the bitter taste of dark coffee.
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