Of the more than 6 million Alzheimer’s patients in the U.S. age 65 or older, nearly two-thirds are women. A new study may help explain the gender gap — and offer clues to new treatments for helping patients of both sexes fight back.
may help explain the gender gap — and offer clues to new treatments for helping patients of both sexes fight back.
In the brain, one waste product is a protein called tau. Too little tau can damage nerve cells, explain researchers David Kang, PhD, and JungA"Alexa" Woo, PhD, who led the study. But too much becomes toxic and can lead to neurodegenerative diseases such as Alzheimer’s. to “tag” or signal the body that extra tau should be removed. In the city analogy, ubiquitin is like attaching a sign to a garbage bag, telling waste management to haul the bag away.
“Our study showed USP11 is higher in females than males in both humans and in mice,” Kang says. “That’s already true before the onset of dementia. But once someone has Alzheimer’s disease, USP11 is much higher — regardless of sex.”that shows women may be more vulnerable than men to higher levels of tau, possibly explaining why women are affected by the disease more often than men.
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