A large international study has identified 27 loci in the human genome with genetic variants that increase the risk of ADHD. This is more than twice as many as previous studies have found. Why do some people get ADHD, while others do not? And how early in life or in the womb is the seed of ADHD s
A study that examined over six million genetic variants was conducted on 38,691 individuals diagnosed with ADHD and 186,843 individuals without ADHD. This enabled the identification of 27 genetic risk variants associated with the prevalent neurodevelopmental disorder.
“The study emphasises that ADHD should be seen as a brain developmental disorder, and that this is most likely influenced by genes that have a major impact on the brain’s early development,” says Professor Ditte Demontis of the Department of Biomedicine at Aarhus University. Credit: Aarhus University
In addition, the researchers found that the genetics that increase the risk of ADHD particularly affect genes that are expressed in neurons, especially dopaminergic neurons.
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