Data prior to current outbreaks suggested resurgence of the disease, with waning immunity from smallpox vaccination contributing to spread
in February which warned monkeypox cases were rising also attributed this to the cessation of widespread smallpox vaccination, given that virus has been declared by WHO as eradicated.
Between 2010 and 2019, cases re-emerged in Liberia and Sierra Leone after a four-decade absence and in Central African Republic after three decades, More data and laboratory analysis is needed to confirm this, however, and for now it is just a theory. Sequencing of the virus in laboratories is occurring, and we should know within days whether the virus has changed.
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