Semaglutide produces significant weight loss in most people with obesity. When should it be prescribed, and what are the pitfalls?
. These price ranges are often cost-prohibitive and unsustainable, especially because these medications are intended for long-term use.. Therefore, these medications are usually not considered by patients who have Medicare or Medicaid insurance.
Because insurance coverage varies and out-of-pocket costs can be prohibitive, many individuals seek other ways of acquiring semaglutide. The off-label use of semaglutide 2.0 mg for obesity is scientifically supported and safe, whereas the use of compounded semaglutide is risky due to lack of regulation.
Compounded semaglutide should be avoided, given that these products are not controlled by the FDA, andIn our clinical practice, patients have reported advertisements for"generic semaglutide" compounded with vitamins like vitamin B12 or B6. This is a significant area of concern because some vitamins are toxic at high doses.
We discussed the dangers of compounded semaglutide with our patient and told her that this isn't something we recommend prescribing. If the patient didn't want to wait for semaglutide 2.4 mg to be available at her pharmacy, we discussed alternative medications used for the management of obesity, such as other FDA-approved GLP-1 agonists and
. In this case, the patient opted to wait for semaglutide 2.4 mg because she preferred a weekly injectable medication, given her busy lifestyle as a new mom.
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