Alzheimers is a devastating diagnosis for people suffering from the disease, as well as their families, but a group of researchers feels that they are one step closer to finding a cure.
Alzheimer's disease affects about 5.7 million people in the US and is the leading cause of age-related dementia today. Many people suffering from AD face a myriad of challenges including the lack of effective treatments, reliable biomarkers, or preventive strategies. Unfortunately, several promising drug candidates in the past have failed in clinical trials so researchers are still searching for new preventions or therapies to combat the development of AD.
It is these two proteins that the US-led research team is looking to develop effective immunotherapy for via a new vaccine to remove brain plaques and tau protein tangles.
The research teams claims that recent success in their tests with mice supports progression to human trials in years to come, sparking hope in he field."Our approach is looking to cover all bases and get past previous roadblocks in finding a therapy to slow the accumulation of Aβ/tau molecules and delay AD progression in a the rising number of people around the world," says Professor Petrovsky.
However, one downside of the potential vaccine is that it could not currently be used as a preventive measure in healthy subjects due to the need for frequent administration of high concentrations of immunotherapeutic drugs, which are a class of drugs targeting the immune system to either kickstart or suppress immune function.
However, if future human trials are successful, the new paper concludes that the new combined vaccination approach could potentially be used to induce strong immune responses to both of the hallmark pathologies of AD in a broad population base of vaccinated subjects with high MHC ) class II gene polymorphisms, stating that, “This synergistic model suggests that combinatorial/multi-target therapies directed at the accumulation of both amyloid and tau pathologies may be more effective in the...
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