US will stretch monkeypox vaccine supply with smaller doses

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US will stretch monkeypox vaccine supply with smaller doses
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The Biden administration declared monkeypox a public health emergency last week in an effort to slow the growing outbreak that has infected more than 8,900 Americans.

WASHINGTON — U.S. health officials on Tuesday authorized a plan to stretch the nation’s limited supply of monkeypox vaccine by giving people just one-fifth the usual dose, citing research suggesting that the reduced amount is about as effective.

White House officials said the new policy would immediately multiply the 440,000 currently available as full doses into more than 2 million smaller doses. The FDA authorized the approach for adults 18 and older who are at high risk of monkeypox infection. Younger people can also get the vaccine if they are deemed high risk, though they should receive the traditional injection, the agency said.“We feel pretty strongly that the two doses are necessary because, in part, we don’t have any evidence that three, six, eight months later people will be adequately protected by a single dose,” said Dr. Peter Marks, the FDA’s vaccine chief.

But some experts and advocates worried that with little data to support the policy, it could backfire if it reduces vaccine effectiveness. The shallower injection is thought to help stimulate the immune system because the skin contains numerous immunity cells that target outside invaders. Both the U.K. and Canada have adopted a single-dose vaccine strategy prioritizing people who face the highest risk from monkeypox. And health departments in several large U.S. cities adopted a similar strategy amid limited supplies, including New York, San Francisco and Washington.

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