Unprecedented Speed: Scientists Discover 30 New Natural Compounds

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Unprecedented Speed: Scientists Discover 30 New Natural Compounds
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Researchers were able to discover and characterize new ribosomally synthesized and post-translationally modified peptides at an unprecedented speed and scale. Modern medicine makes extensive use of drugs that bacteria naturally produce. One of the most noteworthy natural products is penicillin, a

iBioFAB accelerates the biological engineering process by integrating artificial intelligence/machine learning with automation. Credit: Julia Pollack

“This is just the tip of the iceberg,” said Mitchell. “There’s a disparity in what we know today in terms of known molecules versus what nature has the capacity to produce. Like 100 to one at least.” In a new paper resulting from a massive collaborative effort at the University of Illinois Urbana-Champaign, researchers were able to discover and characterize new ribosomally synthesized and post-translationally modified peptides at an unprecedented speed and scale using the Illinois Biological Foundry for Advanced Biomanufacturing. Credit: Carl R.

Out of the new compounds discovered, three were found to have antibacterial properties. When tested against, which are highly virulent antibiotic-resistant bacteria, the newly discovered antibacterial RiPPs were found to be effective at killing the dangerous bacteria. The researchers say this could be a new avenue for discovering compounds that are effective against bacteria that are resistant to current antibiotic drugs.

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