Cilia are thin, eyelash-like extensions on the surface of cells. They perform a wide variety of functions, acting as mechanosensors or chemosensors, and play a crucial role in many signaling pathways.
." Components of the intraciliary transport system"walk" on the microtubule to deliver cargo between the cell body and the ciliary tip to ensure a constant supply of materials.encoding components within the intraciliary transport machinery could lead to ciliopathies.
Cytoplasmic microtubules in KANSL2-deleted cells repolymerise more slowly after depolymerisation treatment. Microscopic images of primary podocytes five min after removal of the depolymerisation reagent. Microtubules are labeled with α-tubulin . Centrosomes are labeled with γ-tubulin . Nuclei are labeled with DAPI . Credit: MPI of Immunobiology and Epigenetics, AkhtarThe intraciliary transport system is essential because it is needed to build a functional cilium.
Although tiny protrusions, these sensory organelles are incredibly important to cells. Ciliopathies, which affect organs as diverse as the kidney, liver, eye, ear, and central nervous system, remain challenging for biological and clinical studies.
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