An interdisciplinary research team led by the University of California, Los Angeles (UCLA) discovered that a drug already approved by the Food and Drug Administration (FDA) for eye disease, verteporfin, stopped the replication of SARS-CoV-2, the virus that causes COVID-19. Their laboratory study ide
Scientists have found that verteporfin, a drug already approved by the FDA for eye disease, stopped the replication of SARS-CoV-2, the virus that causes COVID-19.
The lead researchers were investigating the Hippo pathway, which controls the size of organs in the body, in earlier National Institutes of Health–funded studies of the Zika virus, which can cause undersized brains in infants. Noticing that this pathway also seemed to have virus-fighting effects, they launched the current study investigating SARS-CoV-2.
The scientists found that in the cultured human cells, both the original strain and Delta variant of SARS-CoV-2 activated the Hippo pathway in the first few days after infection. When they silenced this pathway and increased YAP, the virus replicated itself more. They team also pretreated cells with verteporfin, which blocks YAP in the eye disease known as choroidal neovascularization, and then infected them with SARS-CoV-2.
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