Cystic fibrosis is one of the most common fatal hereditary diseases worldwide. 👨🔬❤️ A recently approved therapy in the EU brings lasting improvement in cystic fibrosis and is an option for nearly 90% of people with CF.
The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis . Researchers from Charité -- Universitätsmedizin Berlin and the Max Delbrück Center have just recently published their findings in the.* According to their research, this form of medication improves the symptoms of CF in many patients.
Two years ago, a research group headed by Charité showed that combination therapy involving three drugs -- elexacaftor, tezacaftor, and ivacaftor -- is effective in a large portion of patients with cystic fibrosis, a hereditary disease, meaning that the treatment noticeably improves both lung function and quality of life. Now, the team headed by Prof.
In the current study, the researchers show that a combination of elexacaftor, tezacaftor, and ivacaftor results in less viscous respiratory secretions and decreasing inflammation and bacterial infection in the lungs of cystic fibrosis patients."What's more, the effects lasted over the entire one-year study period. This is really important because previous medications caused a rebound in the bacterial load in the airways," explains Dr.
"We plan to forge ahead with our research on how to make treatments that address cystic fibrosis via the molecular defects that cause the disease -- like the triple medication combination studied here -- even more effective. This includes starting treatment in early childhood with the goal of preventing chronic lung changes wherever possible," Mall notes.
The researchers are also working to advance their understanding of mucus defects in cystic fibrosis and develop new mucolytics, drugs that thin and loosen the mucus. This research could also benefit patients with common chronic inflammatory lung diseases such as asthma and COPD.Cystic fibrosis is one of the most common fatal hereditary diseases worldwide. As many as 8,000 children, teens, and adults are living with the disease in Germany today.
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