To ward off aging, stemcells must take out the trash ucsandiego CellStemCell
, prioritizing quality over quantity. This helps them make fewer mistakes in the process, as misfolded proteins can become toxic to cells if allowed to build up.damage are inevitable, so the researchers set out to understand how stem cells ensure these proteins are properly discarded.
In most cells, damaged or misfolded proteins get individually tagged for disposal. A mobile protein destroyer called the proteasome then finds the labeled proteins and breaks them down into their original amino acid components. But in the new study, the researchers found proteasome activity was especially low in HSCs.
"What's very unusual here is this pathway was thought to only be triggered as an extreme stress response, but it's actually the normal physiological pathway that's used by stem cells," said Signer."This emphasizes how critical it is for stem cells to prevent stress so they can preserve their health and longevity."
"The body really can't risk losing its stem cells, so having this stockpile of raw materials makes them more protected against rainy days," said Signer."Stem cells are marathon runners, but they also need to be world-class sprinters when the circumstances call for it."
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