The Y chromosome, which normally confers male characteristics, features large amounts of repetitive DNA, which meant it was difficult to compile a complete sequence until now
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Twenty years after the Human Genome Project was declared complete, the Y chromosome has been fully sequenced for the first time.or one X and one Y chromosome. Having a Y usually – but not always – results in an embryo developing male characteristics.. Because it normally has no paired chromosome to swap pieces with prior to sexual reproduction, it is especially likely to accumulate bits of repetitive DNA.
Because of this, the “completed” human reference genome announced in 2003 was actually far from complete. “The Y chromosome just kept being pushed aside,” says at the Jackson Laboratory for Genomic Medicine in Connecticut. “It’s a hard chromosome to complete because of all the repetitive sequences.”
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