Nature research paper: The co-evolution of the genome and epigenome in colorectal cancer
. At present, genomics detects driver alterations or mutational processes that inform on drug sensitivity but is blind to potentially clinically actionable biology governed by the epigenome. The observation that epigenetic changes occur in regulatory regions of known cancer driver genes in the absence of somatic mutations argues for the importance of epigenomics for genomic medicine. Certainly, the interaction between somatic mutations and SCAAs remains challenging to unravel.
One of the most intriguing results was the evidence of reactivation of developmental genes during tumorigenesis. Those genes are usually silenced in somatic tissue, and the reactivation of the genes in these families and their involvement in tumorigenesis has been postulated before in the context of glioblastoma tumorigenesisas an enabler of growth and adaption. We identified a group of TFs with decreased accessibility that were related to interferon signalling.
For library preparation, the transposed sample was supplemented with 1 µl of 10 µM Nextera i7 PCR primer, 1 µl of 10 µM Nextera i5 PCR primer and 12.5 µl of NEBNext Q5 High-Fidelity 2× PCR Master Mix .
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