LONDON, Feb 11 — Having genetically higher levels of the sex hormone testosterone increases the risk of developing diabetes and some types of cancer in women, and reduces diabetes risk but raises some cancer risks in men, according to research published yesterday. The findings, from the largest...
The findings, from the largest study to date on links between testosterone and disease, show the importance of studying men and women separately. — ©Kzenon/shutterstock.com
The findings, from the largest study to date on links between testosterone and disease, show the importance of studying men and women separately, the scientists who led the research said — and point to the need for caution in using testosterone supplements or hormone-reducing therapies., used genetic data from more than 425,000 people registered in the UK Biobank to identify 2,571 genetic variations linked to differences in levels of testosterone.
High testosterone also raises the risk of breast and endometrial cancers in women, the study found, and increases the risk developing polycystic ovary syndrome — a hormonal disorder that affects menstruation — by 51 per cent. The results give a unique insight into the disease impacts of testosterone, and “emphasise the importance of considering men and women separately in studies, as we saw opposite effects for testosterone on diabetes,” said Katherine Ruth, a genetics specialist at Britain’s Exeter University who co-led the study.
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