Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That's really the huge breakthrough -- nobody had been able to figure out which of the hundreds of thousands of these assemblies are most highly populated,' said the senior author.
Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function.
"It is the main player that balances excitation and inhibition in the brain," said lead author Chang Sun, Ph.D., a postdoctoral researcher in the Vollum Institute at Oregon Health & Science University."It affects all aspects of brain function, from motor function, to memory and learning, and also emotion and anxiety."
The receptor is defined by five-sided, or pentameric, assemblies derived from 19 different subunits, each of which give rise to a vast number of configurations that may or may not be clinically relevant. In this case, researchers painstakingly isolated native assemblies from mice and then infused them with common medications used to treat insomnia and postpartum depression."This study shows the dominant assemblies and states of the GABA receptor," Gouaux said.
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