Taking a lesson in evolutionary adaptation from octopus, squid HarvardResearch nature
, Anti-CRT1 is specific to expressed CRT1 as it did not label another CR expressed in HEK293 cells. Representative of 3 independent transfections. Scale bar = 30 µm., Fluorescence-detection size-exclusion chromatography trace of CRT1 pentamer and SDS-page gel of final EM sample, representative of 4 independent purifications., TMD z-slices of 3D reconstructions from CRT1 in corresponding detergent conditions. Inset number indicates overall map resolution.
L-MNG stabilized an asymmetric TMD conformation, while GDN resulted in a well ordered and symmetric TMD, and the best overall resolution. Attempts to reconstitute the receptor in lipid nanodiscs resulted in profound aggregation., Representative cryo-electron micrograph of CRT1 in GDN detergent micelle from dataset of 4043 dose-fractionated micrographs. Scale bar indicates 100 nm., 3D classification results; good classes selected for further processing are boxed in red.
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