Time will tell if it works for humans.
The company's goal is to inject liver cells from a donor into the lymph nodes of sick recipients. This can lead to the protrusion of miniature organs in the body. These mini-livers are thought to compensate for useless ones.The treatment succeed in mice and pigs."In this study, a human liver disease was modeled in swine, and liver cells transplanted into lymph nodes were capable of forming ectopic livers that cured all of the animals of otherwise fatal liver disease.
"Showing that our cellular therapy was able to safely and effectively induce organogenesis – the forming of a novel, a well-vascularized organ within the body – in multiple models of liver disease in large animals was a crucial step toward beginning our forthcoming clinical trial for patients with end-stage liver disease who are currently ineligible for standard liver transplantation.
“It’s very promising,” says Valerie Gouon-Evans, a stem-cell biologist with a focus on liver regeneration, who is not involved in the research or with the company. “I’m really happy … this idea is getting into the clinic.”Eric Lagasse from LyGenesis — who is a stem-cell biologist at the University of Pittsburgh, has spent years researching cell-based treatments for liver disease.
Around 10 years ago, he was experimenting with the idea of injecting cells from healthy livers into diseased ones in mice. Only a small number ofWhen Lagasse and his colleagues later performed autopsies on those survivors, “I was very surprised,” he recalled. “We had a mini liver present … where the lymph node would be," he said.Orthotopic liver transplantation continues to be the only effective therapy for patients with end-stage liver disease.
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