Stanford scientists implant human cells into a rat’s brain — and get it to do things
Inside their small furry heads, Stanford rats have brains that are a little bit human.
The goal “is to understand psychiatric disorders at the biological level, so that we can find effective therapeutics,” said, professor of psychiatry and behavioral sciences at the Stanford School of Medicine, who led the research. “We can’t subject your brain to a variety of nasty stuff and then take it out and look at it. That’s called murder,” said Stanford bioethicist, director of the Stanford Program in Neuroscience, who was hired by the university to evaluate the project’s ethical issues. “This is a good way to learn more about human disease in a way you can’t in humans.”
The animals offer other research opportunities, as well. They could be used to study how the healthy brain develops, or is harmed by toxic chemicals or social deprivation. “I know of the many concerns and sorrows which are associated with the lives and outcomes of these children,” said genetic researcher Katherine Timothy, who long ago recognized and described the disorder. The research “will help give the medical community a better understanding of abnormal neuronal development,” she said, “and hopefully, in the future, give better ways we might be able to treat and improve neuronal function.
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