Substantial reductions in body weight across BMI categories, as well as improved body composition, were achieved with tirzepatide in adults for chronic weight management, according to the latest results of the SURMOUNT-1 study.
Moderator Gabriella Lieberman, MD, endocrinologist and head of the Israeli Center for Weight Management, Sheba Medical Center, Ramat-Gan, Israel, welcomed the study but also expressed caution. "It's very potent, but as we see generally with potent therapies, I think it will change how we look at nutritional advice and the role of the dietician will change.
The percentages of participants reaching target weight reductions of ≥ 5%, ≥ 10%, ≥ 15%, ≥ 20%, and ≥ 25% were recorded. Over 90% achieved ≥ 5% weight loss, irrespective of BMI and tirzepatide dose, while 55.5% and 62.9% in the 10-mg and 15-mg groups achieved ≥ 20% weight loss, and 35.0% and 39.7% in the 10-mg and 15-mg groups achieved ≥ 25% weight loss, respectively.
"We want loss of fat not lean mass, and we know that we lose around one part lean to three parts fat mass when on a diet and exercise regimen," he went on to explain."We see exactly this [balance of lean-to-fat-mass loss] here with 33.9% total fat mass reduction in the treatment group compared with 8.2% in the placebo group."
With respect to patient-reported outcomes based on the 36-item Short-Form Health Survey , Aronne said that physical functioning scores significantly improved at 72 weeks compared with placebo, particularly in participants with physical function limitations at baseline.
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