Ovidio Guzman is one of El Chapo's four sons who inherited his father's trafficking empire after his conviction on US murder and drug charges in 2019.
Mr Guzman was captured again in January after an intense firefight. The US requested his extradition in February.
Mr Guzman controlled the first fentanyl lab set up by Los Chapitos around 2014 and has "overseen the explosion of their fentanyl trafficking activity and profits", according to an indictment unsealed in April by US prosecutors in New York. Two of the six counts Mr Guzman faces in Chicago carry a mandatory life sentence, prosecutors said, according to the Tribune.
Mr Guzman waived his right to a detention hearing and will be held without bail until trial, a spokesperson for the US Attorney's office in Chicago said. His next court date is scheduled for November.Fentanyl, a highly addictive synthetic opioid, is responsive for nearly 200 American deaths a day, a toll that has strained US-Mexico relations and put domestic pressure on the Biden administration to slow the spread of the deadly drug.
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