SLAMF7 engagement superactivates macrophages in acute and chronic inflammation

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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation
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Elevated levels of the protein SLAMF7 drives pathogenic inflammation common in RheumatoidArthritis and could also be a source of inflammation in CrohnsDisease and COVID19. SciImmunology

We thank F. Zhang, I. Korsunsky, and S. Raychaudhuri for the advice on bioinformatic analysis; M. Gurish and G. Keras for the assistance recruiting patients and processing samples; W. Apruzzese for the helpful discussions; J. Toska for the help with Western blots; and patients for the participation. Sorting was performed in the BWH Human Immunology Center. We thank the members of the AMP RA/SLE Phase 1 Network for their contributions.

Individual members of the AMP RA/SLE Phase 1 Network are listed alphabetically: Jen Anolik, William Apruzzese, Joan M. Bathon, Ami Ben-Artzi, David L. Boyle, Brendan Boyce, S. Louis Bridges, Vivian Bykerk, Kevin Deane, Edward DiCarlo, Laura Donlin, Tom Eisenhaure, Andrew Filer, Gary S. Firestein, Lindsy Forbess, Susan Goodman, Ellen Gravallese, Peter K. Gregersen, Joel Guthridge, V.

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