Patients experienced significant improvement in their symptoms, even up to 20 weeks after they had stopped taking the medication. Mount Sinai researchers have reported promising results from a clinical trial of rocatinlimab, a new monoclonal antibody therapy that is tailored to individual patients,
Eczema, also known as atopic dermatitis, is a chronic skin condition characterized by dry, itchy, and inflamed skin. It is a common condition that affects people of all ages, but it is most prevalent in infants and children. Eczema can cause the skin to become red, scaly, and crack, leading to discomfort, pain, and itchiness.
According to the researchers, the results of the trial suggest that rocatinlimab has the potential to change the genetic makeup of a person’s eczema in the long term and potentially sustain lasting results even after the therapy is discontinued. The drug works by inhibiting OX40, an immune molecule that plays a key role in activating inflammatory cells, which contributes to the development of eczema and other inflammatory diseases.
Percent change from baseline in the Eczema Area and Severity Index score was assessed as the primary endpoint at week 16, and significance versus placebo was achieved with all active rocatinlimab doses doses compared to placebo . All active dose cohorts also continued improving after week 16, and most patients maintained the response for at least 20 weeks off treatment.
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