Secondary CV Prevention Benefit From Polypill Shown

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Secondary CV Prevention Benefit From Polypill Shown
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Compared with separate medications in people with a prior MI, a polypill containing ASA, a statin, and an ACEI provided progressively greater protection from a second CV event over the course of the SECURE trial. ESCCongress

. For atorvastatin and ramipril, the target doses were 40 mg and 10 mg, respectively, but different versions of the polypill were available to permit titration to a tolerated dose. Usual care was provided by participating investigators according to ESC recommendations.hypertensionWhen the events in the primary endpoint were assessed individually, the polypill was associated with a 33% relative reduction in the risk of CV death .

"Probably, adherence is the most important reason of how this works," Fuster said. Although there were no substantial differences in lipid levels or in systolic or diastolic blood pressure between the two groups when compared at 24 months, there are several theories that might explain the lower event rates in the polypill group, including a more sustained anti-inflammatory effect from greater adherence.

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