Scientists have created embryo models to help study the mysteries of early human development, the medical problems that happen before birth and why many pregnancies fail.
While previous, Hyun said the latest ones model an embryo after it has implanted in the uterus. Real human embryos can be extremely hard to see at that stage because they burrow into the uterus. Each team’s models vary in the techniques used and how complete they are, he said, with some mirroring not just the embryo but the very beginnings of the placenta and yolk sac, too.
“If we can experimentally model this period, then we can finally start asking questions about how human development happens in those very early stages that are normally hidden within the body of the mother,” said author Berna Sozen, who studies developmental stem cell biology at Yale University. Jacob Hanna of the Weizmann Institute of Science in Israel, an author of a yet-to-be-reviewed paper, said in an email that his group’s model also mirrors human embryo development up to day 14 after fertilization. He said the structures include all embryonic membranes as well as membranes outside the embryo.Down the road, Zernicka-Goetz said human embryo models could be used to explore the effects of the environment and chemicals on early development.
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