Understanding of molecular basis of cancer could pave the way for novel treatments. Researchers have conducted an in-depth study on the proteins involved in various cancerous tumors, revealing insights that genome sequencing alone cannot provide. By deciphering the behavior of proteins in cancer ce
National Institutes of Health“In our efforts to develop better cancer therapies, this new analysis of the proteins driving tumor growth is the next step after cancer genome sequencing,” said senior author Li Ding, Ph.D., the David English Smith Distinguished Professor of Medicine at Washington University. “Through our past work sequencing the genomes of cancer cells, we identified almost 300 genes driving cancer.
Beyond the function of individual proteins, such data also allow the researchers to understand how proteins interact with one another to fuel cancer growth. If the levels of two proteins correlate with one another — for example, when one is present at high levels and the other always is as well — this can indicate that the two proteins act as partners. Disrupting the interaction may be a promising way to block tumor growth.
“For some cancers, even with mutations having the potential to generate tumor antigens, if there is no abnormal protein expressed, or very little, such mutations may not be targetable for treatment,” Ding said. “This could be an explanation for why some patients don’t respond to immunotherapy, even when it seems like they should.
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