Researchers have illuminated one of the important ways that cells respond to stress. The findings could also be relevant to Alzheimer's, ALS and other diseases in which this mechanism may be abnormally active.
Researchers at Weill Cornell Medicine have illuminated one of the important ways that cells respond to stress. The findings could also be relevant to Alzheimer's, ALS and other diseases in which this mechanism may be abnormally active.
The study's first author, Dr. Ryan Ries, was a Weill Cornell Graduate School of Medical Sciences doctoral student during the research.Stress granules contain many different mRNAs from the cell, but not a random selection. Dr. Jaffrey and his team previously showed that mRNAs that are found in stress granules are often chemically tagged with a small cluster of atoms called a methyl group which attaches to adenosine, one of the mRNA building blocks.
While the new finding significantly advances the understanding of the basic biology underlying m6A and stress granule formation, it may also be relevant to neurodegenerative diseases.
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