Restoring eye tissue postmortem could pave the way for reviving other types of brain tissue
Few biological facts seem as irrevocable as brain death. It has long been assumed that when we die, our neurons die with us. But a new study on the neuron-packed tissue of the eye is beginning to challenge that dogma.
Most retina studies are done in animals, primarily mice. But mouse retinas lack the macula, a key region found in human eyes that picks out fine details, so they are not an ideal model. Human eye tissue from autopsies often takes hours to obtain and is dead before scientists can study its function. But what if you could revive it?
For the study, the researchers first tested how long mouse retinas could send electrical signals after the animals were euthanized. They were able to restore this activity up to three hours later—and found that a lack of oxygen was the main factor in irreversible loss of function. They then investigated human eyes that the researchers obtained from organ donors very soon after brain or cardiac death.
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