Researchers have identified new gene variants that influence your risk of ADHD and autism. In the group of neurodevelopmental disorders, ADHD and autism have a number of things in common: They are two of the most frequent child psychiatric diagnoses; both are highly heritable; and, although the fu
The study examines genetic variations in the genomes of 34,462 people diagnosed with autism spectrum disorder and/or ADHD, and 41,201 control subjects without these diagnoses . For each person, 8.9 million frequently occurring genetic variants have been examined, spread across the entire genome.
“We have succeeded in identifying both shared genetic risk variants and genetic variants that differentiate the two developmental disorders,” says Professor Anders Børglum of the Department of Biomedicine atand iPSYCH, Denmark’s largest research project within psychiatry, which is behind the study. Researchers have also discovered a gene variant that increases the chance of autism while also decreasing the volume of a particular brain region in the general population, but the complementary variant raises the risk of ADHD while also increasing the volume of the same brain area.
“The autism diagnosis is typically made before an ADHD diagnosis. So if, for example, the person is also hyperactive and finds it difficult to concentrate, this may well be slightly drowned out by the autism symptoms, and we may not see the ADHD challenges,” explains Anders Børglum.
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