Scientists still don’t understand the biology behind the feeling of nausea—or how to stop it—but a new study in mice identifies a possible key player.
Whether we’ve got the flu or have had too much to drink, most of us have experienced nausea. Unlike other universal sensations such as hunger and thirst, however, scientists still don’t understand the biology behind the feeling—or how to stop it. A new study in mice identifies a possible key player: specialized brain cells that communicate with the gut to turn off the feeling of nausea.
that induce nausea behavior in mice. Rodents can’t throw up, but they curl up in discomfort when they feel nauseous. Zhang and her colleagues showed the excitatory neurons in the area postrema are responsible for these behaviors by stimulating the cells. The findings suggest GIP activates the newly identified inhibitory neurons, which in turn block the excitatory neurons in the area postrema and. Although the study focuses on the role gut-secreted GIP plays in suppressing nausea, Zhang adds that there are probably additional factors in the body that can also activate inhibitory neurons to produce the same effect.
New medications would be particularly beneficial for cancer patients, who frequently cite nausea as a main reason they cannot adhere to treatment regimens, adds Stephen Liberles, the study’s senior author and a molecular neuroscientist at Harvard.
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