Researchers have found a possible antidote for a deadly death cap mushroom toxin.
worldwide. Symptoms may appear as soon as six hours after ingestion and include nausea, vomiting and diarrhea. If a person isn’t treated immediately, the toxins can cause liver and kidney damage that can lead to death within 48 hours after ingestion. There is no antidote currently available, but people can be treated with fluids, activated charcoal and other therapies.to determine which human genes the toxin triggers to cause cell damage and death .
The team then screened a library of more than 3,000 drugs approved by the U.S. Food and Drug Administration for molecules that could inhibit STT3B’s action. The team found that the dye indocyanine green could stop the protein from doing its job and prevent human cells in lab dishes from dying after being treated with alpha-amanitin.
In tests with mice poisoned with alpha-amanitin, the dye reduced liver and kidney damage and increased survival rates if given one to four hours after poisoning. Waiting eight to 12 hours to administer the antidote reduced its effectiveness, the team found, probably because irreversible organ damage had already occurred.
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