Science, Space and Technology News 2024
Duke-NUS Medical School scientists have discovered the WWP2 gene’s vital role in kidney disease progression, offering a promising new target for therapies to combat chronic kidney disease and potentially save millions of lives worldwide.
Chronic kidney disease or CKD is a global health concern contributing to high mortality rates worldwide. Singapore is particularly affected, ranking fifth in the world for new cases of kidney failure, with approximately six new patients diagnosed daily. In the advanced stage of kidney disease, kidney tissue becomes fibrotic, resulting in permanent scarring and irreversible organ damage.
Duke-NUS scientists show that the WWP2 gene plays a critical role in advancing tissue scarring in chronic kidney disease. The panels in the image demonstrate how the presence of WWP2 results in more fibrotic tissue , while WWP2 deficiency results in less fibrosis . Credit: Duke-NUS Medical School To this end, the team is in talks with venture capitalists to develop inhibitors of WWP2 to treat heart and kidney disease.
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