The discovery from UCLA could open the door to new treatments for obesity and type 2 diabetes.
Oct. 17, 2023 – A process your body uses to stay warm in cool weather could one day lead to new therapies for obesity.
Brown fat is different from the fat typically linked to obesity: the kind that accumulates around the belly, hips, and thighs. That’sfat. White fat stores energy; brown fat burns it. That’s because brown fat cells have more mitochondria, a part of the cell that generates energy.After dissecting the necks of eight human cadavers, Srikanthan and her team traced the sympathetic nerve branches in the fat pad above the collarbone – where the largest depot of brown fat in adults is stored.
“GLP-1 agonists have been shown to increase activity in rodents and humans, but likely indirectly, via activation of specific regions in the brain,” explained Varman Samuel, MD, PhD, an associate professor of medicine at the Yale School of Medicine, and chief of endocrinology for the VA Connecticut Healthcare System.
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