WASHINGTON, Oct 31 — Toxic protein clusters thought responsible for the cognitive decline associated with Alzheimer’s disease reach different regions of the brain early and then accumulate over the course of decades, according to a new study Friday. The research, published in Science Advances,...
WASHINGTON, Oct 31 — Toxic protein clusters thought responsible for the cognitive decline associated with Alzheimer’s disease reach different regions of the brain early and then accumulate over the course of decades, according to a new study Friday., is the first to use human data to quantify the speed of the molecular processes leading to the neurodegenerative condition, and could eventually have important implications for how scientists design treatments.
“One is very detailed data from PET and various different datasets we’ve put together, and the other thing is the mathematical models we’ve been developing over the past ten years.” This in turn results in memory loss, personality changes and inability to carry out daily functions associated with the condition, which affects 44 million people globally.Past research, mainly performed on animals, suggested the aggregates form in one region then spread throughout the brain, much like how cancer spreads.
An analogy from the Covid pandemic is how travel bans between nations generally proved ineffective at stopping the spread of the virus, because it was already replicating within the countries trying to keep it out. Alzheimer’s disease is classified according to what are known as “Braak stages,” and the team found it took around 35 years to progress from stage three, when mild symptoms first become apparent, to stage six, the most advanced.
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