SPONSORED: UT Health San Antonio is investing $5 million in cryo-electron microscopy, entering the hottest realm in structural biology today.
By using South Texas’ first cryo-electron microscopy technology, researchers can develop novel drug therapies to fight diabetes, obesity, heart attack, stroke, dementia and cancer. Lijia Jia, Ph.D., manages this NASA-quality control room of multiple computers, the cryo-EM system and an electron gun that aims the beams at flash-frozen protein samples.
Cryo-EM is complementary to existing structural biology technologies at UT Health San Antonio. X-ray crystallography, for example, exposes a protein crystal to X-rays, diffracting the X-ray beam in directions according to the protein’s structure. There is also nuclear magnetic resonance spectroscopy, which demonstrates behavior of an atom nucleus when it is placed in a powerful magnetic field.
Visualizing a protein in all its glory at the subatomic level “is like being able to see a dime on the surface of the moon,” Elizabeth V. Wasmuth, Ph.D., said of the cryo-EM suite. Separate multimillion-dollar awards from the Cancer Prevention and Research Institute of Texas aided the scientists’ recruitments. Olsen joined UT Health San Antonio from the Medical University of South Carolina, and Wasmuth was recruited from the Memorial Sloan Kettering Cancer Center and the Rockefeller University in New York City.
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