Research published in the scientific journal Clinical and Experimental Immunology on March 9 shows that a peptide (small protein) called PEPITEM could provide a revolutionary approach to reducing the risk of type 2 diabetes and other obesity-related diseases such as hepatic steatosis (fatty liver).
journal suggests that a peptide called PEPITEM may be a revolutionary way to reduce the risk of type 2 diabetes and other obesity-related diseases such as fatty liver. The study used an animal model of obesity to investigate whether administering PEPITEM by a slow-release pump could prevent or reverse the effects of a high-fat diet on the pancreas.
’s Institute of Inflammation and Ageing and Institute of Cardiovascular Sciences. Dr. McGettrick said: “We have found a new therapeutic approach that could provide new drugs to tackle the root cause of obesity-related conditions by preventing the damage caused by systemic inflammation.in the adiponectin-PEPITEM pathway, which is involved in controlling the onset and severity of auto-immune and chronic inflammatory diseases.
The latest research, published in Clinical and Experimental Immunology, shows that the adiponectin-PEPITEM pathway also connects obesity, the low-level inflammatory response that is driven by it, and changes in the pancreas that precede diabetes. The researchers also looked at the potential of PEPITEM to reverse the changes brought on by obesity, by feeding the animals a high-fat diet prior to treating with PEPITEM. Excitingly, they saw similar results. Dr. Asif Iqbal commented: “Until now we have understood very little about how the inflammation that accompanies obesity drives pathology. These results show us that PEPITEM can both prevent and reverse the impact that obesity has on metabolism.
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