Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.
By Tarun Sai LomteOct 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in Cell, researchers integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types to trace the cellular origin of nearly 6,000 proteins in the aqueous humor .
In addition, it cannot be inferred whether a given messenger RNA is translated; thus, studying proteome-wide relevance to human disease is challenging. The team confirmed gene expression of 5,923 proteins within RNA-seq data. There were 5,887 locally expressed genes in the eye. Unsupervised cluster analysis of 5,923 genes revealed cell-type-dependent clustering.
Further, the team also tested uveitis patients and observed a significant increase in markers from several immune cells . Besides, they observed molecular damage from uveitis in other retinal cell types, such as amacrine cells, bipolar cells, and cone photoreceptors. Further, the authors analyzed AH from patients with Parkinson’s disease . Among 48 PD-relevant proteins, 18 were present in the AH, including nine significantly increased PD.
Malaysia Latest News, Malaysia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Mid-Down Integrated College: New school set to openA plan for the 600-pupil school in the Saintfield and Crossgar area has been approved.
Read more »
Redefining united data protectionWhere adopting a resilient and integrated approach to backup and disaster recovery makes sense
Read more »
The Tesla killer? Toyota's EV breakthrough will allow cars to travel 745 miles on a single 10 minute...Toyota has said it 'close' to being able to mass manufacture potentially revolutionary solid-state batteries that could offer double the range of existing electric cars.
Read more »
The Tesla killer? Toyota's EV breakthrough will allow cars to travel 745 miles on a single 10 minute...Toyota has said it 'close' to being able to mass manufacture potentially revolutionary solid-state batteries that could offer double the range of existing electric cars.
Read more »
Met Police officers ‘sick’ of Suella Braverman pressuring them to ‘reach beyond law’ after jihad proteOne senior Met officer accused the Home Secretary of using the forces' response to the protests to make 'political gain'
Read more »
Arsenal star sent clear transfer warning as exit will ‘not be easy’ amid £60m Chelsea linksAccording to reports, it will 'not be easy' for Aaron Ramsdale to find a new club during the January transfer window if he opts to leave Arsenal.
Read more »