Revolution in Pet Sterilization: Gene Therapy Offers Long-Term Contraception for Cats — Research study’s findings |
Scientists at Massachusetts General Hospital have successfully tested a single dose of anti-Müllerian hormone gene therapy as a long-term contraception method for cats, presenting a potential alternative to surgical spaying. The research demonstrated the gene therapy to be safe and well tolerated over a two-year period. More studies are needed for confirmation and to address scalability.Currently, there are no contraceptives capable of producing permanent sterilization in companion animals.
In 2017, Pépin and his collaborators were the first to publish the contraceptive potential of AMH in rodents. The researchers treated six female cats with the gene therapy at two different doses, and three cats served as controls. A male cat was brought into the female colony for two four-month-long mating trials. The researchers followed the female cats for more than two years, assessing the effect of the treatment on reproductive hormones, ovarian cycles, and fertility.
The collaborative research team, which includes investigators from MGH, the Center for Conservation and Research of Endangered Wildlife at the Cincinnati Zoo and Botanical Garden, and at the Horae Gene Therapy Center at the University of Massachusetts Medical School, received funding from The Michelson Found Animals Foundation, which is offering a $25-million prize to scientists to develop a single-treatment nonsurgical sterilization method for cats and dogs.
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