The new study focused on an anti-inflammatory drug used for rheumatoid arthritis and found that it may reverse some of the effects of aging on the blood system in mice.
The researchers found that an inflammatory signal released from old bone marrow, IL-1B, was critical in driving aging in blood stem cells. The drug, anakinra, returned the blood stem cells to a younger, healthier state. and oldCould revitalizing old blood slow the process of aging? Recent research has shown that young blood has a rejuvenating effect on aging hearts, muscles, and brains when infused into older bodies.
Over time, these stem cells start to change: They produce fewer red blood cells, leading to anemia, and fewer immune cells, which raises the risk of infection, they said. They also start having trouble maintaining the integrity of their genomes, which can lead to blood cancers. They found that over time, the niche deteriorates and is overwhelmed with inflammation, leading to dysfunction in the blood stem cells. The team narrowed in on one particular inflammatory signal released from the damaged bone marrow niche, called IL-1B, which was critical in driving these aging features.
"We know that bone tissue begins to degrade when people are in their 50s. What happens in middle age? Why does the niche fail first?" Passegué said. "Only by having a deep molecular understanding will it be possible to identify approaches that can truly delay aging."Researchers say they found a way to tell from a person’s blood how severe their depression is, the risk of developing severe depression in the future and the risk of future bipolar disorder.
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