Circulating tumor DNAs may be the key to detecting micrometastases. 🧬
to cure cancer, but determining its necessity is another challenging issue.
In treating colon cancer, chemotherapy aims to eliminate micrometastases, cancer cells that are not visible on radiologic pictures but move through the bloodstream and cause the disease to return or spread to other body regions. Using ctDNA to detect these invisible cells, researchers can now determine which individuals are more likely to suffer micrometastases and hence benefit from treatment.
"Stage II colon cancer presents a unique challenge," stated Anne Marie Lennon, Ph.D. and director of the division of gastroenterology and hepatology at Johns Hopkins University School of Medicine. "In stage I colon cancer, patients do not receive chemotherapy because their prognosis for survival is over 90 percent. The risk of discomfort and toxicities from the therapy outweigh the benefits it can provide.
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