The study found risks of these events happening to individual patients appears to be rare - about 1 per cent of people taking Ozempic were diagnosed with stomach paralysis, for example.
The study found risks of these events happening to individual patients appears to be rare - about 1 per cent of people taking Ozempic were diagnosed with stomach paralysis, for example.A new study suggests weight loss drugs can lead to serious digestive problems.
For the study, which was published as a research letter in JAMA, researchers at the University of British Columbia sifted through a random sample of more than 16 million insurance claims from a prescription drug database that covers about 93 per cent of all outpatient prescriptions in the US.They looked for patients who were prescribed two injected drugs — semaglutide and liraglutide.
To ferret out who those patients might have been, researchers looked for people who were diagnosed with obesity at least 90 days before they started the medication and excluded any who were also diagnosed with diabetes or who were taking any other drug to control their blood sugar. In relative terms, that means people taking the injected drugs were more than three times more likely to develop stomach paralysis compared with those taking Contrave.
In the group of roughly 600 patients who were taking Ozempic, there were four cases of gastroparesis or stomach paralysis, two cases of pancreatitis, no bowel obstructions, and five who developed biliary disease. By excluding them from the study, Sodhi said, they were able to tease out more carefully what might be linked to the drug versus the disease.
"While GLP-1 agonists are generally well tolerated, there is a low incidence of serious side effects," Dr Ian Musgrave, a molecular pharmacologist at the University of Adelaide, said in a statement on the study given to the non-profit Science Media Centre in the UK. Another may be that while the study authors controlled their data for things like age, sex, alcohol use, smoking and high cholesterol, they didn't compare the effect of body mass index, or BMI.
Treatment decisions should be made together with a healthcare provider who can evaluate the appropriateness of using a GLP-1 based on assessment of a patient's individual medical profile," the statement said.
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